Pharmacologie clinique et biopharmaceutique

Abstrait

Zebra Fish (Danio rerio) Diving into Bipolar Disorder

John D Andrew, Abdul A Hathi, Lino Steffy and Manjula Devi

Bipolar disorder is a chronic neurological disorder. It is the 6th major ailment which affect 1% of the world population. Lithium is the only classic drug available because the molecular mechanisms of remain unclear. It is difficult to establish in vitro adequate models for pathological analysis because of the heterogeneity of this disorders. The active principle of herbal preparations like ginseng, ephedra sinica, Brindle berry, clove etc. are able to decrease the symptoms of bipolar disorder. Zebrafish and human share 71% of the same genes and 82% of genes associated with human diseases and rapid development and easy to handle. Due to this fact scientist improved the usage of Zebrafish in preclinical screening, as a prominent model in drug discovery and development for neurological disorders. Different procedures are available to study the stress or depression level. They are highly sensitive to psychotropic drugs and different methods like novel tank test, light and dark box method, cognitive model, social model and net stress model are some of the behavioral models performed on Zebrafish. Our work summarizes the growing utility of Zebrafish in pharmacy research and its benefits to overcome the hurdles in the discovery of drugs for neurological disorders.