Journal de pharmacocinétique et thérapeutique expérimentale

Abstrait

The Comparable Influence of Intrinsic and Extrinsic Factors on Esomeprazole Pharmacokinetics Following Intravenous and Oral Administration

Haume Shalde

This study aimed to assess the impact of intrinsic and extrinsic factors on the pharmacokinetics of esomeprazole, comparing its intravenous (IV) and oral administration routes. Esomeprazole, a proton pump inhibitor widely used for acid-related disorders, exhibits variable pharmacokinetic profiles due to individual variability and external factors. A randomized crossover design was employed, involving healthy participants receiving both IV and oral esomeprazole under different conditions. Blood samples were collected at predetermined intervals, and plasma concentrations were analyzed using advanced chromatographic methods. The results indicated that intrinsic factors such as age, gender, and genetic variations minimally affected esomeprazole pharmacokinetics, regardless of administration route. Similarly, extrinsic factors like diet, concomitant medications, and smoking showed consistent effects on both IV and oral administration. This suggests that the pharmacokinetic behavior of esomeprazole remains relatively consistent across administration routes and is robust against various factors. These findings contribute to a better understanding of esomeprazole's pharmacokinetic profile, supporting its clinical utility in diverse patient populations. Further research could explore specific mechanisms underlying these observations and their clinical implications.