Pharmacologie clinique et biopharmaceutique

Abstrait

Stem Cell-Derived Neurons for the Treatment of Neurodegenerative Diseases

Haigang Gu

Neurodegenerative diseases are termed for the age-related chronic and progressive loss of structure and function of neurons. Most common neurodegenerative diseases include Alzheimer’s disease (AD) and Parkinson’s disease (PD). So far, no drugs can be used to reverse the neuronal degeneration. Recent progresses in stem cells biology and technology allow us to generate specific types of neurons, such as cholinergic and dopamine neurons from stem cells, with defined culture conditions. These stem cell-derived neurons have been used for cell replacement therapy in animal models of neurodegenerative neurons, such as AD and PD. Here, I summarized recent progresses of stem cell-derived cholinergic and dopamine neurons and their applications in AD and PD.