Journal de pharmacocinétique et thérapeutique expérimentale

Abstrait

Significant Method in Drug Disposition and is that the Most Relevant Method in Stereoselectivity

Annan Valdese

Stereoselectivity in drug metabolism can't solely influence the pharmacologic activities; tolerability, safety, and bioavailability of medicine directly, however additionally cause completely different forms of drug–drug interactions.Thus, assessing stereo selectivity in drug metabolism is of nice significance for pharmaceutical analysis and development (R&D) and rational use in clinic. Though there square measure numerous strategies accessible for assessing stereo selectivity in drug metabolism, several of them have shortcomings. The indirect technique of natural action strategies will solely be applicable to specific samples with purposeful teams to be derivative or type complicated with a chiral selector, whereas the direct technique achieved by chiral stationary phases (CSPs) is dear. As a detector of natural action strategies, mass spectroscopy (MS) is very sensitive and specific, whereas the matrix interference continues to be a challenge to beat. Additionally, the utilization of nuclear resonance (NMR) and bioassay in chiral analysis square measure price noting. This review presents many typical samples of drug stereo selective metabolism and provides a literature-based analysis on current chiral analytical techniques to indicate the importance and challenges of stereo selectivity assessing strategies in drug metabolism [1].