Revue internationale de recherche et développement en pharmacie et sciences de la vie

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PREFORMULATION STUDIES AND PREPERATION OF DITHRANOL LOADED SOLID LIPID NANOPARTICLES

Shagufta Khan, Tripti Tiwari, Shweta Tyagi, Mithun Bhowmik, Amit Joshi, Balkrishna Dubey

Dithranol belongs to the keratolytic category, which is widely used drug in the treatment of psoriasis. The drug is practically insoluble in water. Many conventional dosage forms for psoriasis treatment have been have been formulated earlier, but they did not show good results. Hence in the present study, it was attempted to formulate dithranol in the form of solid lipid nanoparticle. Solid lipid nanoparticles of dithranol were obtained by adaption of lipid dispersion method. Preformulation studies were performed to check the compatibility of drug and excepient for the preparation of formulation by DSC and no interaction was found. Solubility study, partition coefficient determination, UV analysis, HPLC study, FTIR study were also performed. After the preformulation studies Dithranol loaded solid lipid nanoparticles was also prepared. Hence it was concluded that solid lipid nanoparticle of dithranol could be formulated.