Journal de pharmacocinétique et thérapeutique expérimentale

Abstrait

Pharmacokinetics Analysis of Copen, a unique anticancer Semi artificial by-product of Osthole, in Rats when Intragastric and endovenous Administration

Shentu J

Copen is one in all of the key semi artificial derivatives of osthole with apparent anticancer interest. certainly the bioavailability and gender-related pharmacokinetic properties of copen in rats were decided during this look at. Sprague-Dawley rats were intragastrically and intravenously administrated of various doses of copen, severally. The concentrations of copen in rat plasma had been decided with the aid of a LC-MS/MS methodology. Pharmacokinetic parameters had been calculable employing a drug and statistics (DAS) software system. implemented mathematics analysis become carried out victimization freelance two-sample t-check with p-values but 0.05 due to the fact the level of significance. The outcomes indicated that maximum plasma concentrations (Cmax) for copen have been finished at nine.