Pharmacologie clinique et biopharmaceutique

Abstrait

Pharmacokinetic Study of Zaltoprofen Spherical Agglomerated Dense Compacts Canvassed with Commercial Product

Hari Krishna E, Rama Mohan Gupta V and Jyothi S

Pharmacokinetic parameters including AUC_0-t, AUC_0-∝, C_max, T_max, T_1/2 and Elimination rate constant (K_el) were determined from plasma concentrations of Zaltoprofen spherical agglomerated dense compacts by 2⁴ factorial design canvassed with a commercially available formulation of Zaltoprofen. Foremost spherical agglomerates of Zaltoprofen prepared with PEG 6000 which is hydrophilic polymer and evaluated for different compressibility parameters and in vitro dissolution studies, studies indicated that the drug release can be modulated by using hydrophilic polymers and the best one compressed as dense compacts and appraised for pharmacokinetic parameters in rabbit models. Sensitive and selective high performance liquid chromatographic method was used to determine drug plasma concentrations with good linearity in the range of 0.5 to 20 μg/mL (r2=0.995, n=7). Study ascertained meliorated values of AUC_0-24 (15.789 ± 12.9, 97.334 ± 7.478).