Journal de pharmacologie cellulaire et moléculaire

Abstrait

New Methods for Studying Cancer Metastases Using Metabolomics

Alpaslan Tasdogan

90% of cancer patients’ deaths are the result of metastasis. The lack of reliable and sensitive tools to record metabolic processes in metastatic cancer cells has hampered our understanding of the involvement of metabolism during this process. We go over the current research methodologies for investigating I cancer cell metabolism in primary and metastatic tumours, and metabolic interactions between cancer cells and the tumour microenvironment

All cellular processes revolve around metabolism since it is what ultimately produces and uses the ATP needed for cellular activity. Numerous diseases, including cancer, can develop as a result of metabolic changes. Different metabolic pathways can be activated and suppressed by cancer cells. In addition, metabolic alterations found in cancer cells as opposed to non-cancer cells suggest possible metabolic weaknesses that could be medically modified to slow the progression of cancer. Understanding the metabolic control of cancer cells has advanced significantly in recent years, particularly when it comes to the metabolism of primary tumours.However, there is still much work to be done in order to fully understand how cancer cells regulate their metabolism during metastasis. Each and every biological activity depends on metabolism.