Pharmacologie clinique et biopharmaceutique

Abstrait

Methods in Clinical Pharmacology: Unlocking the Power of Precision Medicine

Harada Yohsuke

Precision medicine has emerged as a transformative approach to healthcare, offering tailored treatment strategies based on an individual's unique genetic, molecular, and clinical characteristics. Clinical pharmacology plays a pivotal role in the realization of precision medicine's potential by providing the scientific foundation for optimizing drug therapies. This abstract provides an overview of the essential methods employed in clinical pharmacology to unlock the power of precision medicine. One of the core methods in clinical pharmacology is pharmacokinetics, which involves studying how drugs are absorbed, distributed, metabolized, and eliminated within the human body. Modern techniques such as mass spectrometry and advanced imaging modalities enable precise measurements of drug concentrations and their interactions with physiological systems, enhancing our ability to tailor dosing regimens to individual patients. Pharmacodynamics is another critical aspect of clinical pharmacology, focusing on how drugs exert their effects on target tissues or cells. Genomic, proteomic, and biomarker-based approaches allow us to identify patient-specific factors influencing drug response, enabling the selection of the most effective and least toxic therapies. Methods in clinical pharmacology are vital in realizing the potential of precision medicine. These methods encompass pharmacokinetics, pharmacodynamics, innovative clinical trial designs, pharmacogenomics, and data-driven approaches. By harnessing these tools, healthcare professionals can tailor drug therapies to individual patients, maximizing efficacy, minimizing adverse effects, and ultimately improving patient outcomes in the era of precision medicine.