Journal de pharmacocinétique et thérapeutique expérimentale

Abstrait

Impact of Pain Pill on Antiplatelet Effects of Oral P2Y12 Receptor Inhibitors

Slobby RL

Morphine and P2Y12 receptor inhibitors square measure each suggested in patients with acute myocardial infarct. pain pill could impede epithelial duct absorption of many oral medication including P2Y12 blood platelet receptor inhibitors.The aim of this review was to critically discuss drug–drug interactions between oral P2Y12 receptor inhibitors and pain pill per presently offered data supported the findings of experimental, data-based and randomised clinical studies. pain pill is glucuronidated and sulfated at positions three and 6; the plasma concentration ratios correlate positively with birth weight, that in all probability reflects raised liver weight with increasing birth weight. Moreover, pain pill clearance correlates absolutely with age and birth weight. Steady-state pain pill plasma concentrations square measure achieved when 24-48 hours of infusion, however the glucuronide substance plasma concentrations don't reach steady state before sixty hours. The morphine-3-glucuronide substance has lower clearance, a shorter half-life and a smaller distribution volume compared with the morphine-6 substance, that is that the most active morphine-like agonist. Standard doses cause constipation, retentiveness and metastasis depression [1].