Journal de pharmacocinétique et thérapeutique expérimentale

Abstrait

Formulation and pharmacological medicine of NSAID Floating Compression Coated Mini-Tablets

Veerareddy PR

Present evaluation is supposed to expand the NSAID (KTM) effervescent floating mini-capsules victimization compression coating method. Mini-pills have the blessings of every capsules and multiparticulate formulations like pellets. the most principle of floating mini-tablets is carried out to decrease the thorn impact of KTM on the abdomen by using averting the direct touch with the internal organ mucous membrane and getting a low dose for prolonged periods. KTM mini-tablets have been ready victimization 4 metric linear unit round flat punches and compression lined with hydroxypropyl methylcellulose and effervescent mixture. The ready capsules were evaluated for weight variant, thickness, friability, hardness, drug content material, in vitro buoyancy and in vitro unharness and additionally the first-rate components was subjected to greater in vivo examination. The prepared mini-drugs exhibited satisfactory chemistry