Revue internationale de recherche et développement en pharmacie et sciences de la vie

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FORMULATION AND EVALUATION OF ESOMEPRAZOLE MAGNESIUM DIHYDRATE MULTIPLE UNIT PARTICULATE SYSTEM ( PELLETS) AS A DELAYED RELEASE DOSAGE FORM

Nagarjuna Naik.R, Laksmano Rao Potti, Rama Kotaiah Mogali, Prasad Rao.M, Sivasankar.R, Beera valli

The present study was an attempt to formulate and evaluate enteric coated tablets for Esomeprazole magnesium dihydrate delayed release multiparticulate to reduce the Gastrointestinal tract side effects.The delayed release multiple units were prepared by using fluid-bed werster technology.These multiple units are selected by seal coating, drug coating and enteric coating.These Esomeprazole magnesium dehydrate were evaluated for assay, acid resistence, drug release,dissolution, Kinetic studies of Innovator and Optimized formulation, Stability studies of Optimized formulation. This study concluded Esomeprazole magnesium dihydrate can be prepared by using combination of polymers studied and we can reduce the GI tract side effects.