Revue internationale de recherche et développement en pharmacie et sciences de la vie

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ESTIMATION OF RADIOPROTECTIVE EFFECTS OF GARCINIA INDICA METHANOL EXTRACT IN SWISS ALBINO MICE

K. Nagendra, H. D. Ramachandran, Akshay Kumar R

The radio protective effectiveness of methanol extract of Garcinia indica against whole body gamma radiation was premeditated in Swiss albino mice. The oral administration of Garcinia indica extract at 800 mg / kg body weight / day for 15 consecutive days before whole body exposure to radiation was found to be effective with the LD50/30 values of 7.21 and 8.83 Gy for irradiation alone and Garcinia indica and irradiation group, respectively, giving a dose reduction factor of 1.42. This effect of Garcinia indica as the modulation of the radiation-induced decrease of reduced glutathione and the radiation-induced increase in lipid per oxidation assessed in the liver and the blood.