Revue internationale de recherche et développement en pharmacie et sciences de la vie

Abstrait

AN OVERVIEW ON MICROWAVE MEDIATED SYNTHESIS

Rina Das, Dinesh Mehta, Harsh Bhardawaj

Microwave-assisted organic synthesis is an enabling technology for accelerating drug discovery and development processes. Microwave organic synthesis opens up new opportunities to the synthetic chemist in the form of new reaction that are not possible by conventional heating and serve a flexible platform for chemical reaction. This review focuses on the advances in the developing of innovative application of microwave mediated synthesis. The efficiency of microwave flash-heating chemistry in dramatically reducing reaction times (reduced from days and hours to minutes and seconds) has recently been proven in several different fields of organic chemistry. The time saved by using focused microwaves is potentially important in traditional organic synthesis but could be of even greater importance in high-speed combinatorial and medicinal chemistry. The study presents examples that demonstrate the significance of these advantages to industrial application.