Journal de pathologie dentaire et de médecine

Abstrait

Unveiling Cementogenesis: From Cellular Activity to Periodontal Stability

Zuping Domon

Cementogenesis is a crucial biological process that plays a vital role in the maintenance of periodontal health and integrity. It involves the formation and development of cementum, a specialized mineralized tissue that covers the root surface of teeth and facilitates the attachment of periodontal ligaments. This abstract aims to provide an overview of the cementogenesis process, highlighting its key cellular and molecular mechanisms. The process of cementogenesis begins with the differentiation and activation of cementoblasts, which are responsible for the synthesis and secretion of cementum matrix components. These cells undergo a series of complex cellular events, including migration, proliferation, and maturation, under the influence of various growth factors, cytokines, and signaling pathways. During the deposition of cementum matrix, several distinct types can be identified, including acellular cementum, cellular mixed stratified cementum, and cellular intrinsic fiber cementum. Each type possesses unique structural and functional characteristics, contributing to the overall stability and attachment of the tooth within the periodontal tissues. Understanding the intricacies of cementogenesis is crucial for advancing periodontal research, diagnosis, and treatment. Dysregulation of cementum formation can lead to various pathological conditions, including cementum defects, root resorption, and compromised periodontal attachment. Therefore, further investigations into the molecular mechanisms underlying cementogenesis hold promise for developing innovative therapeutic approaches to prevent and treat periodontal diseases. In conclusion, cementogenesis is a fascinating biological process that contributes to the maintenance of periodontal health. This abstract provides a concise overview of cementogenesis, emphasizing its cellular and molecular aspects. A deeper understanding of cementogenesis will undoubtedly pave the way for novel interventions aimed at promoting periodontal integrity and improving clinical outcomes.