Journal de recherche en immunologie muqueuse

Abstrait

Understanding Mucosal Infections: Unraveling the Complex Interactions at Epithelial Interfaces

Sonya D

Mucosal infections represent a significant global health challenge, affecting diverse anatomical sites such as the respiratory, gastrointestinal, and genitourinary tracts. This abstract provides a comprehensive overview of the current state of research on mucosal infections, focusing on the intricate interactions between pathogens and the host epithelial barriers. The review encompasses the latest findings in mucosal immunology, microbial pathogenesis, and therapeutic strategies, emphasizing the dynamic nature of mucosal surfaces and the sophisticated defense mechanisms evolved by the host. Key topics covered include the unique features of mucosal immunity, the role of mucins and antimicrobial peptides in mucosal defense, and the intricate crosstalk between commensal microbiota and the host epithelium. Additionally, we explore the diverse strategies employed by pathogens to evade mucosal defenses, such as antigenic variation, biofilm formation, and immune modulation. The abstract also discusses emerging technologies and methodologies, such as advanced imaging techniques and omics approaches, driving breakthroughs in mucosal infection research. Furthermore, the abstract highlights the translational aspects of mucosal infection research, discussing the development of vaccines, antimicrobial agents, and probiotics aimed at bolstering mucosal immunity and preventing or treating infections. By synthesizing current knowledge and identifying research gaps, this abstract aims to inspire further investigations into mucosal infections, ultimately contributing to the development of innovative therapeutic interventions and public health strategies.