Rapports de transplantation : accès libre

Abstrait

Umbilical Cord Blood Transplantation Graft Procurement and Early Direct Charges Vs Transplantation from a Related Haploidentical Donor

Nagasaki D

Alternative patron allogeneic hematopoietic cell transplants( HCTs), analogous as double umbilical cord blood transplants( dUCBT) and haploidentical related patron transplants( haplo- HCT), have been shown to be safe and effective in adult cases who do not have an HLA-identical stock or unconnected patron available. Utmost transplant centers have committed to 1 of the 2 volition patron sources, indeed with a lack of published randomized data directly comparing issues and relative data on the cost- effectiveness of dUCBT versus haplo- HCT. We conducted a retrospective study to estimate and compare the early costs and charges of haplo- HCT and dUCBT in the first 100 days at 2 US transplant centers. Forty- nine benefactors of haplo- HCT (at 1 center) and 37 with dUCBT (at another center) were included in the analysis. We compared graft accession, inpatient/ outpatient, and total charges in the first 100 days. The results of the analysis showed a significantly lower cost of graft accession and lower total charges (for 100- day HCT survivors) in favor of haplo- HCT. Importantly, to control for the obvious shortcomings of comparing costs at 2 different transplant centers, acclimations were made predicated on the current (2018) original pay envelope index and inflation rate. In the absence of further guidance from a prospective study, the cost analysis in this study suggests that haplo- HCT may affect in early cost savings over dUCBT and may be preferred by transplant centers and for cases with farther limited resources.