Médecine communautaire et éducation à la santé

Abstrait

To Assess the Clinical Pattern of COVID-19 among the Vaccinated People

Sai Priya Nimmagadda, Nethra Somannagari, Shubham G, Saumya LG, Venu Bolisetti, Srikanth Gadam

Background: Since the World Health Organisation has declared COVID-19 a pandemic on 11 March 2020, it has become a significant health concern at an alarming rate. There have been tremendous efforts by the countries to provide adequate care to the people affected by SARS-CoV-2. India is running one of the worldʼs largest vaccination programmes.COVID-19 vaccines are designed to prompt an immune response that, recognises and blocks the virus .However people with comorbidities who have a weakened immune response may still be at risk even after vaccination.

Aim: The aim of our study is to assess clinical pattern of disease among vaccinated COVID-19 patients and to find the correlation between comorbdities and the severity of disease outcome in post vaccinated COVID-19 patients.

Materials and method: A descriptive cross sectional study was done taking COVID-19 patients from GANDHI Hospital, Secunderabad admitted during the months of May to August 2021.Gandhi Hospital is a territory care facility which has been the heart of pandemic management. On a random basis 1000 COVID-19 patients were taken, out of which 99 were vaccinated either with single or both doses. The data was collected via telecommunication using a semi structural standardised pro forma and the responses were noted. The data was entered in a MS Excel sheet and analysed using IBM SPSS statistics.

Results: In our study the association between comorbidity and outcome was found to be statistically significant (p=0.028).Out of the 61 patients with comorbidities 35(57.4%) fully recovered, 16(26.2%) partially recovered and 10(16.4%) died. We have found that post vaccinated COVID-19 patients with comorbidities have longer hospital stay probability (61.6%) and oxygen requirement (65.6%).

Conclusion: Our study showed that among the breakthrough infections, the risk of mortality is approximately 8 times more in patients with comorbidities. This shows that COVID-19 is still possible even after vaccination are hitting people with one or more comorbidities particularly hard.