Journal international de l'inflammation, du cancer et de la thérapie intégrative

Abstrait

The Role of Sulforaphane on Duchenne Muscular Dystrophy by Activation of Nrf2

Cheng-Cao Sun, Jing-Yu Pan, Shu-Jun Li and De-Jia Li*

Sulforaphane (SFN) possesses powerful chemo-preventive effects and plays a crucial role on oxidative stress and inflammatory. In our recent study, SFN treatment could relieve muscular dystrophy in mdx mice by activating Nrf2 (NF-E2 related factor 2). Moreover, our findings indicated that SFN-activated Nrf2 alleviated muscle inflammation in dystrophin-deficient mdx mice through suppressing NF-κB signaling pathway. Collectively, SFNinduced Nrf2 molecular pathway might be a promising approach for treatment of the patients with Duchenne muscular dystrophy.