Journal de pathologie clinique et expérimentale

Abstrait

The Role of Acute Phase Proteins in Induction of Tension of Nonspecific Resistance System in Various Clinical Phenotypes of Myasthenia

Klimova EM and Kalashnikova JV

Introduction: All over the world autoimmune diseases and one of the classic examples of such diseases - myasthenia gravis - are on the rise. This progressing autoimmune disease characterized by pathological muscle weakness and increased fatigue. The literature describes the cause of myasthenia as production of autoantibodies to acetylcholine receptor subunits thereof. However myasthenia inherent immunological phenomena are not described in the literature, except the concentration of interleukins. Methods: All the 69 patients were examined and divided into 3 groups depending on the morphological damage of the thymus: a group of "myasthenia without morphological damage of the thymus" represented by 30 patients, a group of "myasthenia with hyperplasia of the thymus" represented 23 patients, a group of "myasthenia with thymoma" represented by 16 patients. We used these laboratory methods: microscopic determining phagocytic activity of granulocytic neutrophils; studying oxygen-dependent metabolism of neutrophil granulocytes (NBT-test); determining of C-reactive protein in blood serum; photometric determination of haptoglobin content (with rivanol); photometric determination of ceruloplasmin content by Ravin; nephelometric determination of concentration of C3 component of the complement.