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Marco Rigatti, Agostino Menditto, Renato De Stefano, Civetta Antonio, Umberto Landri, Roberto Passaro, Mario Passaro, Fabrizio Paolillo Diodati, Alessandro Nicotra, Emio Cafarelli, Ermanno Barletta, Antonio Esposito, Pierluigi Pozzuoli
Objective: to investigate the effects of a novel multi-ingredient supplement comprised of high dose whey protein, to improve maternal and perinatal outcomes in pregnant women
Methods: This was an observational retrospective study. Women who received oral supplementation with a novel multi-ingredient supplement (PSIPROTO ®), comprised of high dose whey protein, were compared with women who did not. Inclusion criteria were singleton pregnancy with body mass index (BMI) higher than 25. The primary outcome of the study was the incidence of adverse pregnancy outcome
Results: 400 women, 200 for each group, were included in the study. The two groups were similar in terms of maternal demographics, and both of them had similar BMI. Maternal age and smoking rate were also similar. Women who received the intervention had a significantly lower maternal weight gain, and lower risk of low birth weight. Notably, 4 women in the intervention group reported intrauterine growth restriction before the intervention, and solved after 2 months of supplementation.
Conclusion: Our retrospective cohort of singleton gestations with BMI >25 showed that PSIPROTO is a safe and efficacy supplement in pregnancy.