Journal de recherche sur la pharmacie moléculaire et les processus organiques

Abstrait

Synthesis, characterization and in vitro antimicrobial activity of carboxamides

Divyata Lava

A series of new carboxamides: (R)-(3,4-dioxocyclobut-1-en-1-yl)-N-phenylpiperidine-3-carboxamide derivatives were synthesized. The characterization of synthesized compounds was done by IR, 1H NMR, mass spectroscopy and LC-MS. All these synthesized compounds were tested for in vitro antimicrobial against various bacterial and fungal strains in N, N-dimethyl formamide and Dimethyl sulfoxide. It is observed that almost all the compounds showed moderate antimicrobial activity and N, N-dimethyl formamide is better solvent than dimethyl sulfoxide