Journal du diabète clinique

Abstrait

Study of the Relationship between Chitotriosidase and Atherosclerosis in a Sample of Egyptian Patients with T2DM

Hanan Mahmoud Ali Mahmoud*, Salwa Seddik Hosny, Hanaa Fathey Abd El Samee, Maram Mohamed Maher, Meram Mohamed Bekhet, Ahmed Mohamed Bahaa El Din and Amr Mahmoud Mohamed Abd –El Hady Saleh

Background: Diabetes mellitus type 2 (T2DM) is the leading cause of cardiovascular morbidity and mortality
worldwide. Poor glucose control, hypertension, and dyslipidemia are the main factors that increase the risk of
atherosclerotic disease in T2DM.
Aim: Study the relationship between Chitotriosidase and the development of atherosclerosis in a sample of
Egyptian patients with T2DM.
Method:This case control study was conducted on 75 subjects, divided into 2 groups: 50 T2DM patients which
were further divided into two groups (Ia) Non atherosclerotic, (Ib) Atherosclerotic patients, according to Carotid
artery intimal thickness (CIMT>0.9 mm), 25 healthy subjects as control. Fasting plasma glucose, 2h post prandial
plasma glucose, Carotid artery intimal thickness using carotid artery duplex, HbA1c, Lipid profile (cholesterol,
triglycerides, LDL-C, HDL), Serum creatinine, AST, ALT and Serum Chitotriosidase were assessed.
Result: There was a statistical significant increase in serum Chitotriosidase in Atherosclerotic diabetic patients
than Non atherosclerotic diabetic one (p value˂0.001), (2.5-3.98) ng/ml) vs. (1.1 (1-1.25) ng/ml) respectively. Also
Serum chitotriosidase was positively correlated with blood pressure, glycemic profile, lipid profile and CIMT.
Conclusion: There is increase in serum Chitotriosidase in atherosclerotic diabetic patients than nonatherosclerotic
diabetic one.