Revue internationale des innovations, pensées et idées avancées

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Structures and Biosynthesis of Enediyne Natural Products

Rui Ji1, Fuli Liu2, Lingbin Meng and Xiaolei Chen

Enediyne natural products are important member of natural product family with strong DNA cleavage activity. This biological activity makes them excellent candidates for developing novel antibiotics and antitumor drugs. Highly unsaturated enediyne cores, sugar moieties and aromatic moieties are basic components of structures of enediyne natural products. Genes encoding enzymes responsible for enediyne natural product biosynthesis are clustered in enediyne gene clusters. Each gene cluster consists of dozens of genes that encode enzymes for biosynthesis of enediyne core, sugar moieties and aromatic moieties as well as tailing enzymes.