Journal du diabète clinique

Abstrait

Rogers Syndrome after Growth Hormone Therapy, Childrens Adult Height

Huyn Li

Turner Syndrome (TS) is a genetic disorder characterized by short stature in affected females. Growth hormone therapy (GHT) has emerged as a successful intervention to improve linear growth and maximize adult height in these individuals. This abstract summarizes the effects of GHT on the adult height of children with Turner Syndrome. Several studies have shown that GHT significantly increases adult height in girls with Turner Syndrome. Early initiation of treatment, preferably before the age of 4-6 years, is associated with the best outcomes. The duration of treatment also plays a crucial role, with longer treatment periods leading to greater height gains. GHT not only enhances adult height but also improves growth velocity during childhood and adolescence. The therapy stimulates bone lengthening and overall skeletal development, enabling individuals with Turner Syndrome to achieve a height closer to the normal range for their age group. Factors such as dose, compliance, and genetic variations influence the response to GHT. Appropriate dosage and adherence to treatment regimens are essential for optimal results. Genetic modifiers and variations in the growth hormone receptor gene may impact the growth response and adult height outcomes.