Raman Microspectroscopy Demonstrates Alterations in Human Mandibular
Bone after Radiotherapy

Singh SP; Parviainen I; Dekker H; Schulten EAJM; ten Bruggenkate CM; Bravenboer N; Mikkonen JJ; Turunen MJ; Koistinen AP; Kullaa AM

ISSN: 2155-9872

Journal des techniques analytiques et bioanalytiques

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Raman Microspectroscopy Demonstrates Alterations in Human Mandibular Bone after Radiotherapy

Singh SP, Parviainen I, Dekker H, Schulten EAJM, ten Bruggenkate CM, Bravenboer N, Mikkonen JJ, Turunen MJ, Koistinen AP and Kullaa AM

Quality and alterations in the biochemical composition of bones used for dental implantation after radiotherapy in cancer patients is always a critical and debatable factor. Clinically the irradiated bone is similar to control bone. The aim of this study was to verify any compositional alterations in human mandible bone after irradiation using Raman microspectroscopy. A total of 36 bone biopsies (21-control, 4-cancer and 11-irradiated) were investigated. Data acquisition points were determined under histopathological supervision. Both mineral and matrix constituents were analyzed by computing area associated with of phosphate (958 cm-1), carbonate (1070 cm-1) and matrix (amide I) bands. Unpaired Student’s t-test was employed to measure level of significance. Absolute mineral contents (phosphate and carbonate) were highest in cancerous specimens. Spectral profile and band-intensity calculations suggest proximity of irradiated specimens with control specimens. Significant differences in both matrix and mineral contents were observed when control/irradiated samples were compared against cancerous specimens. However, no significant differences were observed between control and irradiated groups. Irradiated bone is similar to control and cause of implant loss could be related to osteocytes of the surrounding tissue.