Progrès dans la prévention du cancer

Abstrait

Putative Status of Actively Operative Performance Attributes as Determinants of Minimal Platform Oncogenesis in C-Myc Amplification

Lawrence M Agius

Delivery and effective modulation of intrinsically operative c-Myc gene amplification is a referential series of system pathways that appear to condition minimal platform utilization of dimensions that characterizes the outcomes as hyper-proliferation and increased growth rate, on the one hand, and of enhanced apoptotic activity, on the other. A small numerical genetic requirement for oncogenesis appears sufficient in the case of some neoplasms such as human prostatic carcinoma. Thus, targeting c-Myc appears a highly promising endeavor to induce therapeutic regression of neoplasms. On the other hand, loss of dependence on c-Myc of certain subsets of tumors and recurrence after partial regression contrast with the arrest of some neoplasms that have been investigated in certain animal models. In terms that implicate the delivery of transforming potentiality of this amplified master-oncogene, it is significant to view potentiality of the already established increased proliferative rate within contexts of modulated sensitivity for the instability of the genome due to subsequent tumor progression. Accumulation of multiple genetic lesions, as seen in advanced clinically detected tumors, would attest to an autocrine and paracrine series of lesions that include increased apoptosis of neighboring normal cells, and also to the angiogenesis that re-characterizes the malignant transformation process as essentially metastasizing attributes of systemic spread.