Biochimie et physiologie : accès libre

Abstrait

PTGS2 Effectively Suppress Dendritic Cell Immunity

M. Salahuddin, MdSaidur Rahman, A K Paul, Md. Selim Ahmed, and Mohammad Alam Miah

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase (COX), is a key enzyme in prostaglandin biosynthesis,regulates dioxygenase and peroxidase activity. The major metabolites of PTGS2 are PGE2, PGF2, PGD2, PGI2, and TXA2. All of these are steroid and act as immunosuppressive agentsbut differ in their regulation of expression and tissue distribution. It is a well-known fact that PTGS2 prompt and aggrandize the cancer condition by proliferation, differentiation, and migration of carcinogenic cells in different organs in animals including human, therefore considered as a novel target for the prevention of cancer. Several researchers have discoverednumerous pharmacological inhibitors of PTGS2 to prevent the cancer,however prevention and treatment of cancer by inhibiting PTGS2 from dendritic cell has not been properly studied. Therefore, indirect/direct molecular silencing of PTGS2 by siRNA/shRNA or PTGS2 knockout from DC to prevent cancer means PTGS2 mediated DC vaccine may be an attractive approach to prevent cancer in near future.