Journal de pathologie clinique et expérimentale

Abstrait

Prevalence of Chromosome 8 Aneuploidy in Egyptian Acute Myeloid Leukemia Patients using Fluorescence in situ Hybridization

Eyada TM, Botros SK, El Noshokaty EH and Nabil G

Trisomy 8 is one of the commonest recurring aberrations in myeloid hematologic malignancies. This study aimed to detect the prevalence of chromosome 8 aneuploidy in Egyptian AML patients and analyse its prognostic impact. Forty newly diagnosed AML patients were studied. Karyotyping was performed and the presence of chromosome 8 aneuploidy was tested with the FISH technique. Trisomy 8 was detected in 2 cases (5%) of de novo AML patients as a sole anomaly, monosomy 8 in 1 case (2.5%), t(8;21) in 3 cases (7.5%) and t(15;17) in one case (2.5%). Association between chromosome 8 aneuploidy and other laboratory variables could not be assessed owing to the small number of patients showing this aberration. Conclusion: This study provided the opportunity to investigate the incidence of chromosomale 8 aneuploidy in Egyptian AML patients. Further studies using larger sam