Journal du diabète et de la pratique clinique

Abstrait

Preclinical Models of Gravid Diabetes Mellitus

Nomiyama T*

To stop the vicious cycle of diabetes, we need a lesser understanding of the pathophysiology of GDM and the mechanisms of fetal programming convinced by GDM. As preliminarily mentioned, this is an essential bid, because GDM confers short-and long- term health pitfalls for the mama and the fetus, with implicit long- term health consequences in nonage and majority. Still, establishing reason is delicate in mortal and epidemiological studies, which are frequently complicated by confounding multiple factors [1]. Thus, experimental beast models are critical to study the underpinning mechanisms and pathophysiology of GDM. Styles for generating beast models of GDM are different and include the surgical junking of all or part of the pancreas, the use of pharmacological agents, diet- convinced strategies, and inheritable models.