Journal de la maladie d'Alzheimer et du parkinsonisme

Abstrait

Point of View about Erythropoietin in Treatment of Central Nervous System Diseases

Liu-Zhu Yang, Rui-Long Li, Bo Wu, Jin Luo, Zhong Chen, Xin-Ping Yan and Wei Tan

Spinal Cord Injury (SCI) is a complex process which leads to destruction of neuronal tissue and also vascular structure. Recent many studies have shown erythropoietin (EPO) has neuro-protective effects in acute SCI animal models. Alzheimer’s disease (AD), Parkinson’s disease (PD) and SCI belong to central nervous system diseases, a few studies also indicated that EPO may be effective for AD and PD. In this a short review article, we provide a short overview of the animal and human studies on rhEPO in SCI, AD and PD. Further clinical studies should reveal whether derivatives and variants of EPO provide any benefits over the clinical application EPO to against SCI, AD and PD in the experimental studies.