Journal des maladies infectieuses et de la thérapie

Abstrait

Outcomes of Staphylococcus aureus Bacteremia in Patients with Chronic Kidney Disease versus without Chronic Kidney Disease

Shinhye Cheon, Jungok Kim, Kyung Mok Sohn and Yeon-Sook Kim

Objectives: S. aureus bacteremia (SAB) is a leading cause of infection in patients with chronic kidney disease (CKD). Clinical outcomes associated with SAB in patients with CKD and with non-CKD were compared.

Materials and methods: Laboratory and clinical data from patients who were hospitalized with SAB in a tertiary care hospital were reviewed. Linear regression was used to identify independent predictors of 7-day, 30-day, and 90- day mortality.

Results and discussion: A total of 79 patients with CKD and 92 patients without CKD were enrolled from Mar 2014 to Dec 2016. Seven-day and 90-day mortality were increased in patients with CKD compared to patients with non-CKD (7-day mortality, 19% vs. 8.7%, p=0.011; 30-day mortality, 30.4% vs. 23.9%, p=0.058; 90-day mortality, 38.0% vs. 26.1%, p=0.002). Difference of Pitt bacteremia score and persistent bacteremia longer than 7 days among both groups was not statistically significant. High SOFA (sequential organ failure assessment) score and proportion of administration of inappropriate antibiotics was associated with CKD.

Conclusion: SAB bacteremia in CKD was combined with high SOFA score. Administration of inappropriate antibiotics might cause high mortality in patients with CKD.