Otolaryngologie : accès libre

Abstrait

Otolaryngology Cancer Stem Cell Signalling in Head and Neck Cancer Repopulation

Jesus Medina

Patients with head and neck cancer (HNC) experience treatment-related issues that may degrade their health and quality of life (HRQOL). The purpose of this study was to describe the functional status factors and shoulder pain symptom experience that is related to general and domain-specific HRQOL at one month after HNC surgery. In this early study, 29 patients were examined. Overall HRQOL as well as the physical, functional, emotional, and social wellbeing were considered outcome factors. The existence of symptoms and characteristics affecting functional status served as the independent variables.

The objective of the study was to investigate cancer stem signalling during the repopulation response of a head and neck squamous cell carcinoma (HNSCC) xenograft after radiation therapy. The xenografts were made using low passage HNSCC cells, and either sham radiation or 15 Gy in one fraction were then applied to them. Three tumours from each group were collected at various time points for the investigation of global gene expression, pathway analysis, and immunohistochemical evaluation, including days 0, 3, and 10 for controls and days 4, 7, and 12 and 21 after radiotherapy. Following radiation, 316 genes were discovered to be associated with many genes related to stem cells and to exhibit differential expression (p 0.01 and 1.5-fold) at least once in UT-SCC-14 xenografts.