Journal de transplantation clinique et expérimentale

Abstrait

Organ Transplantation Consequences of Immuno Regulation of Human Herpesviruses

Germing Ulrich

Human herpesviruses, such as cytomegalovirus, Epstein-Barr virus, HHV6, HHV7, and HHV8, herpes simplex virus (HSV)-1 and HSV-2, and varicella zoster virus (VZV), have formed intricate connections with the human immune system. This is characterized by the interaction between viral immune evasion mechanisms that encourage the onset of a chronic infection that lasts a lifetime and the induction of a broad moral and cellular immune response that prevents viral disease. In order to develop immunological strategies to prevent and control herpesvirus-associated diseases and understand why immunological dysfunction in transplant patients can lead to disease, as well as the immune parameters that control herpesvirus infection, it has been critical to comprehend the strategies the viruses use to evade immune recognition.