Journal de recherche en immunologie muqueuse

Abstrait

Mucosal vaccines: Strategies and challenges

Yuseok Moon

Adjuvant, Nasal vaccination, Mucosal immune response, and Drug delivery method avenues for administration,Immunological reactions at the mucosa specific tactics By evoking immune response in both mucosal and systemic tissue to guard against pathogen invasion at mucosal surfaces, mucosal vaccination has the potential to be more advantageous than standard parenteral immunisation. Mucosal vaccines, which have been designed to offer a first line of defence at these entrance ports, show great potential for lowering the burden of infectious illnesses. However,there have only lately become a few mucosal vaccinations accessible. This study provides an overview of current developments in a few key areas related to mucosal vaccination, such as suitable delivery routes, acceptable formulations, antigen-sampling and immunological responses of mucosal immunity, as well as methods for enhancing the efficiency of mucosal vaccines. Lastly, the difficulties in creating effective mucosal vaccinations and possible solutions are discussed.

Since mucosal surfaces are constantly in contact with the outside world, they constitute the body’s greatest lymphoid organ. Gut-associated lymphoid tissues (GALTs), such as Peyer’s patches and isolated lymphoid follicles, are crucial for the generation of antigen-specific immune responses in the gut in the mucosal immune system. GALTs interact with the network of T cells and dendritic cells to simultaneously induce and regulate IgA responses and oral tolerance due to their distinct organogenesis properties. Antigens are picked up by M cells in the epithelial layer of these lymphoid organs, and GALT cells then start antigen-specific immune responses. The respiratory tract’s main organised lymphoid structures, the nasopharynx and tear duct-associated lymphoid tissues (NALTs and TALTs), respectively, have been shown to interact with each other. The development of mucosa-associated lymphoid tissues, as well as the induction and control of innate and acquired mucosal immune responses, are all influenced by host-microbe interactions on mucosal surfaces.