Journal de la maladie d'Alzheimer et du parkinsonisme

Abstrait

Molecular Mechanism Underlying PD Pathogenesis-A Possible Role for Sphingosine Kinases and Sphingosine-1-Phosphate

Meenalochani S, Dheen ST and Tay SSW

Parkinson’s disease is a neurodegenerative disorder that results in the degeneration of dopaminergic neurons in the substantia nigra (SNc) of the midbrain. Understanding the molecular mechanisms underlying the cause of Parkinson’s disease (PD) has attracted the attention of many researchers in the last few decades. In spite of the recent technical advances in the field of neuroscience, the complete pathophysiology of PD is not fully understood. Dysregulated sphingolipid metabolism has been shown to underlie the pathophysiology of many neurodegenerative disorders. However, the role of these sphingolipids in the pathophysiology of PD is still not known. This paper focuses on the, metabolic pathways that are involved in PD pathogenesis with emphasis on sphingolipids and the possible role played by them in the pathogenesis of PD.