Toxicologie : accès libre

Abstrait

Micrornas: A Review of Emerging Experimental and Epidemiological Data as a Hugely Beneficial Technique in Agricultural Toxicity Testing Screening

Abdo Manuell

Many biological processes, including development, cell differentiation, proliferation, apoptosis, and tumour growth, are regulated by miRNAs. They can also act as precise, reliable, and sensitive indicators of chemical exposure, according to numerous studies. Current experimental and epidemiological evidence showing dysregulation in miRNA expression in response to fungicides, insecticides, or herbicides were examined in this study. According to Venn's diagrams, let-7, miR-155, miR-181, and miR-21 were found to be often deregulated by at least three different insecticides. In contrast, miR-363 and miR-9 deregulation is connected with fungicide exposure in vitro and in vivo. Additionally, three different herbicides frequently disrupted the expression of let-7, miR-30, miR-126, miR-181, and miR-320.