Journal de transplantation clinique et expérimentale

Abstrait

Manipulating the HIF Pathway in Renal Transplantation, Current Progress and Future Developments

Alexander Hollis, Kamlesh Patel, Tom Smith, Jay Nath, Danie Tennant, Andrew Ready and Christian Ludwig

Renal transplantation is the gold standard treatment for end stage renal disease; however, there are currently not enough suitable organs to meet a growing demand. The Hypoxia Inducible Factor (HIF) pathway comprises a number of oxygen sensitive transcription factors which activate cellular protective functions. Allografts from cadaveric organs make up a large proportion of the organ pool. These organs are subjected to hypoxic and ischemic conditions during the harvesting and transplant process. Manipulation of the HIF pathway may reduce organ damage and improve outcomes. This review evaluates the current evidence for the use of the HIF pathway in renal transplantation and also adds new research conducted into the effect on organ metabolism.