Otolaryngologie : accès libre

Abstrait

Link between Hormones and Autoimmune Allergies

John Cormick

Without exposure to exogenous allergens, IgE identification of auto antigens may exacerbate allergic inflammation.The preponderance of males before puberty and females after puberty in cases of allergy and autoimmune suggests a possible role for sex hormones. An allergic reaction to hormones is a condition known as a hormone allergy. It is an immunological response to the hormones, which may prevent the hormones from functioning normally. Along with variations in the menstrual cycle, it can happen to women perimenstrually. The periodic abundance of the hormone creating a cyclic expression of allergy symptoms is what causes premenstrual allergies. Both allergic reactions to external allergens and reactions to hormone allergens, which are internal to the body, have the same inflammatory pathways.

The immune system's malfunction leads to allergies and autoimmune disorders. The prevalent thinking holds that both of these immune diseases originate from various routes. Their simultaneous beginning in some cases,however, may suggest shared pathophysiological factors, such as a genetic ancestry. By examining the essential components for these processes-T cells, cytokines, mast cells, and genetic factors—this review describes the concurrent presentation of these two illnesses in both its similarities and differences. T cell receptors appear to represent the common denominator in autoimmune, allergic, and atopy illnesses. In light of the modification of the aforementioned crucial components, it will also be examined how environmental stressors affect immune response modulation. The aim of understanding the mechanisms of both ailments is to predict immunomodulation treatment to cure both of these diseases.