Système gastro-intestinal et digestif

Abstrait

Incidental Cholangiocarcinoma is Associated with Poor Outcome in Patients Transplanted for Hepatocellular Carcinoma

Rustam Khan, Safia Awan, Peng Chung Cheow, Chee Kiat Tan and Pik Eu Chang

Background: Hepatocellular carcinoma (HCC) is a common malignancy in Asia for which orthotopic liver transplantation (OLT) offers curative treatment in selected patients. Incidental HCC-cholangiocarcinoma (HCC-CLC) has been associated with poor OLT outcomes. Aims: To examine the prevalence of incidental HCC-CLC in liver explants from patients undergoing liver transplantation for HCC in our center and to examine its association with post-transplant disease recurrence and mortality. Methods: Medical records of all liver transplant patients in our center were reviewed. The presence of HCC-CLC in liver explants was reviewed by experienced pathologists. Factors associated with recurrence of HCC post OLT and post-transplant mortality were analyzed. Survival in patients with incidental HCC-CLC was compared against those without.