Journal du diabète et de la pratique clinique

Abstrait

Impact of Dapagliflozin on Glycemic Variations in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Jian-hua M

To watch changes in blood glycemic varieties and oxidative anxiety when dapagliflozin treatment in patients with recently analyzed T2DM. Techniques. This was a randomized, twofold visually impaired, fake treatment controlled, stage 3 preliminary. A sum of 28 patients with recently determined T2DM to have HbA1c levels of 7.5–10.5% were arbitrarily chosen to get dapagliflozin or fake treatment for 24 weeks. After benchmark information were gathered, we examined glycemic varieties and plasma 8-iso PGF2α level at gauge and at the endpoint. Essential result was the progressions of mean abundancy glycemic trip (MAGE) inside gatherings. Results. Following 24-week dapagliflozin treatment, our information indicated the huge improvement of MAGE with dapagliflozin treatment (P = 0.010). Contrasted and control gathering, patients in dapagliflozin bunch showed decrease in 24-hour MBG (P = 0.026) and lower mean plasma glucose focuses, particularly during periods from 2400 to 0200 and 1300 to 1800 (P < 0.05, resp.). Furthermore, plasma 8-iso PGF2α level was strikingly diminished in the treatment bunch contrasted with the benchmark group (P = 0.034). Ends. Taking everything into account, this investigation shows the capacity of dapagliflozin to improve glycemic varieties and partner with decrease of oxidative worry in patients with T2DM, which may profit the cardiovascular framework.