Journal de biologie des cytokines

Abstrait

HLH is a Rare Condition Characterized by Inappropriate Immune Activation

Jaime Gomez-Laguna

Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) impairs original pulmonary immune responses by damaging the mucociliary transport system, injuring the function of porcine alveolar macrophages and converting apoptosis of immune cells. An imbalance betweenpro- andanti-inflammatory cytokines, including tumour necrosis factor- α and interleukin- 10, in PRRS may vitiate the immune response of the lung. Pulmonary macrophage subpopulations have a range of vulnerability to different PRRSV strains and different capacities to express cytokines. PRRSV infection is associated with an increase in attention of haptoglobin, which may interact with the contagion receptor (CD163) and induce the conflation ofanti-inflammatory intercessors. The balance betweenpro- andanti-inflammatory cytokines modulates the expression of CD163, which may affect the pathogenicity and replication of the contagion in different napkins. With the emergence of largely pathogenic PRRSV, there’s a need for further information on the immunopathogenesis of different strains of PRRS, particularly to develop further effective vaccines. Blinatumomab is a CD19/ CD3- bispecific T- cell receptor- engaging ( BiTE) antibody with efficacity in refractory B- precursor acute lymphoblastic leukemia. Some cases treated with blinatumomab and other T cell- cranking curatives develop cytokine release pattern (CRS). We hypothecated that cases with more severe toxin may witness abnormal macrophage activation touched off by the release of cytokines by T- cell receptor – actuated cytotoxic T cells. We prospectively covered a case during blinatumomab treatment and observed that he developed HLH. He came ill 36 hours into the infusion with fever, respiratory failure, and circulatory collapse. He developed hyperferritinemia, cytopenias, hypofibrinogenemia, and a cytokine profile individual for HLH. The HLH continued to progress after termination of blinatumomab; still, he’d rapid-fire enhancement after IL- 6 receptordirected remedy with tocilizumab. Cases treated with T cell- cranking curatives, including blinatumomab, should be covered for HLH, and cytokine- directed remedy may be considered in cases of life- hanging CRS.