Journal des techniques analytiques et bioanalytiques

Abstrait

Fundamentals and Applications of Impedimetric and Redox Capacitive Biosensors

Adriano Santos, Jason J Davis and Paulo R Bueno

Electroanalyses have brought a huge amount to our understanding of interfaces generally. When applied to surfaces which have been specifically engineered so as to recruit targets from an analytical solution, potent sensors can be derived. These may be based on a multitude of different analytical methods all typified by specific requirements and surface configurations. This short review examines the application of amperometric and impedimetric methods to the detection of biomarkers of clinical relevance. Basic principles are introduced with examples at both planar and “nanofunctionalised” interfaces comprising immobilized antibodies/antigens and oligonucleotide receptors. A particular focus is made of new developments in impedance and impedance derived capacitance spectroscopy.