Système gastro-intestinal et digestif

Abstrait

Full Clinical and Endoscopic Remission Following Fecal Microbiota Transplant with Moderate-Severe Treatment-Resistant Ulcerative Colitis

Mihaela Laszlo and Pascu

Fecal microbiota transplantation (FMT) from healthy donors, is an effective alternative for treatment of Clostridium difficile–associated disease, it is being considered for several disorders such as inflammatory bowel disease, irritable bowel syndrome, and metabolic syndrome.

A 61 year old male with extensive ulcerative colitis since 2010 under biologic therapy from 2012 and with several acute relapses under treatment. The patient has been treated with FMT, clinical and biological remission was achieved.

This case highlights the value of characterizing temporally resolved microbiota dynamics for a better understanding of FMT efficacy and provides potentially useful diagnostic indicators for monitoring FMT success in the treatment of ulcerative colitis.

FMT seems to be a promising alternative treatment of frequent relapses for selected cases of ulcerative colitis