Journal de biochimie et de biologie cellulaire

Abstrait

Exploring the Dynamic World of Cytoskeletal Proteins

Stamatoski B

The cytoskeleton is a highly dynamic and complex network of protein filaments that play a crucial role in maintaining cell shape, supporting intracellular transport, and enabling cellular motility. This abstract provides an overview of our research endeavor to explore the dynamic world of cytoskeletal proteins. We investigate the structural and functional intricacies of microtubules, actin filaments, and intermediate filaments, shedding light on their roles in diverse cellular processes. Our research employs a multidisciplinary approach, combining advanced microscopy techniques, biochemical assays, and computational modeling to gain insights into the dynamic behavior of cytoskeletal proteins. We delve into the mechanisms governing cytoskeletal polymerization, depolymerization, and regulation, as well as their interactions with various cellular components. Furthermore, we examine the implications of cytoskeletal protein dysfunction in human diseases, such as cancer, neurodegenerative disorders, and congenital myopathies. Understanding the intricate biology of cytoskeletal proteins is vital for the development of targeted therapies and drug interventions to combat these pathologies. In summary, our research seeks to unravel the intricacies of cytoskeletal proteins, contributing to a deeper understanding of cell biology and offering potential avenues for therapeutic advancements. By exploring the dynamic world of cytoskeletal proteins, we aim to bridge the gap between fundamental research and clinical applications, ultimately benefiting human health and well-being.