Épidémiologie : libre accès

Abstrait

Evaluation of Different Factors Leading to the Genesis of Alzheimer’s Disease: Research Proposal on Dementia

Yifei Pei

Alzheimer's disease is a neurodegenerative disorder that is featured by the momentary loss of memory and forgetfulness. Alzheimer’s disease and dementia affect millions of individuals all over the globe. Individuals suffering from Alzheimer's or dementia are prone to accidental falls and are at increased risk of life-threatening injuries. Identification of the predisposing risk factors would help to reduce the prevalence and complications of both these diseases in the near future. The present article portrayed a research proposal for evaluating the role of probable factors leading to the genesis of Alzheimer’s disease. The present study would be conducted as a cohort and crosssectional study. The study would be based on quantitative analysis and end-points would be reflected through quantitative data. The study would be conducted on 5000 participants belonging to 4 cities. The cities selected for the present study would be Shanghai, Beijing, Guangzhou, and Wuhan. MMSE would be used to classify different grades of dementia. However, it could not be used to portray the presence of Alzheimer’s disease amongst the study participants. Therefore, plasma Aβ-42/Aβ-40 ratio and plasma TNF-alpha/IL-1β-40 ratio would be implemented for confirming the presence of Alzheimer’s disease. Regression analysis would be conducted for dementia and Alzheimer’s with the individual risk factors. Based on the evaluation of risk factors, a public health model would be planned and implemented. The public health model would involve the family members of affected individuals. Implementation of a public health model is speculated to reduce the progression of Alzheimer’s or dementia.