Journal de biochimie et de biologie cellulaire

Abstrait

Emerging Stem Cell Therapies in Mast Cell Biology

Bashit K

The genesis and development of all higher creatures depend on stem cells, which are the basic building elements of life. The discovery of adult stem cells sparked a therapeutic and regenerative medicine revolution that is still continuing strong and inspired the development of novel treatments for diseases that were once considered incurable. The first instance of a successful stem cell therapy was hematopoietic stem cell transplantation, which is now often used to treat multiple myeloma and adult T-cell leukemia-lymphoma among other illnesses. The autologous transplantation of mesenchymal stem cells is used more frequently to promote the repair of mesenchymal tissue and other tissues, such as the lung and heart, and to treat a variety of illnesses, including diabetes, multiple sclerosis, and stroke. The therapeutic potential of additional adult stem cells, including those from the testicles, breast, intestinal, and inner ear, is now gaining attention. It has become clearer how the underlying epigenetic mechanisms of pluripotency and carcinogenesis work thanks to the discovery of induced pluripotent stem cells. It will be possible to create safer and more precise treatments by doing in-depth research on these epigenetic variations and the physiological changes they cause. It's been known for a long time that mast cells play a crucial and direct role in allergy and inflammatory reactions. These cells influence systemic and local allergic reactions, such as allergic rhinitis and anaphylaxis, in allergic disorders. In addition, several chronic inflammatory disorders are connected to mast cell mediators. Mast cells have a variety of healthy tasks, in addition to their roles in pathological circumstances. These include innate immunity, participation in host defence mechanisms against parasites, immune system immunomodulation, tissue healing, and angiogenesis. Mast cell biology is a field that still needs considerable research despite its growing importance in both physiological and pathological settings. This study provides evidence for the modulation of numerous biological processes in mast cells, including degranulation and endocytosis, by lipid rafts or raft components.