Different Awareness Domains Contributes to Explain Emotional and Behavioral Disorders in Mild Alzheimer’s Disease

Gianna C Riccitelli; Carlo A Defanti; Nadia Parietti; Stefania Rossi; Pietro Tiraboschi; Leonardo Sacco

ISSN: 2161-0460

Journal de la maladie d'Alzheimer et du parkinsonisme

Accès libre

Notre groupe organise plus de 3 000 séries de conférences Événements chaque année aux États-Unis, en Europe et en Europe. Asie avec le soutien de 1 000 autres Sociétés scientifiques et publie plus de 700 Open Access Revues qui contiennent plus de 50 000 personnalités éminentes, des scientifiques réputés en tant que membres du comité de rédaction.

Les revues en libre accès gagnent plus de lecteurs et de citations
700 revues et 15 000 000 de lecteurs Chaque revue attire plus de 25 000 lecteurs

Politiques et éthique de publication

Indexé dans

Index Copernic
Google Scholar
Sherpa Roméo
Ouvrir la porte J
JournalSeek de génamique
Clés académiques
JournalTOC
Infrastructure nationale du savoir de Chine (CNKI)
Bibliothèque de revues électroniques
Recherche de référence
Université Hamdard
EBSCO AZ
OCLC-WorldCat
Catalogue en ligne SWB
Bibliothèque virtuelle de biologie (vifabio)
Publons
Fondation genevoise pour l'enseignement et la recherche médicale
Euro Pub
ICMJE

Liens utiles

Revues en libre accès

Partager cette page

Abstrait

Different Awareness Domains Contributes to Explain Emotional and Behavioral Disorders in Mild Alzheimer?s Disease

Gianna C Riccitelli, Carlo A Defanti, Nadia Parietti, Stefania Rossi, Pietro Tiraboschi, Leonardo Sacco

Background: The relationship between awareness domains and behavioural-psychological symptoms in Alzheimer's disease (AD) is unclear.

Objective: To investigate the effects of awareness domains on mild AD patients’ emotional-behavioural disturbances and caregivers’ stress accounting for demographic and clinical variables.

Methods: Overall awareness and cognitive, emotional and functional domains were investigated in 60 mild AD patients and 60 related caregivers using the Questionnaire of identification of deficits. The patients’ cognitive functioning and psycho-affective/psychiatric symptoms, and their caregivers’ stress, were also assessed. Patients were classified as preserved (AD_AP) and impaired (AD_AI) awareness. Hierarchical linear models were applied to explore the effects of awareness domains on psychological and behavioural measures.

Results: Unawareness was more frequent for emotional and functional disturbances than for cognitive deficits. AD_AP patients were less engaged in social and leisure activities and had higher rates of psycho-affective disturbances, while AD_AI had higher rates of psychiatric and behavioural disorders. Higher global awareness and higher awareness of cognitive alterations respectively explained 32% and 25 % of the variance for depression (both p: <0.001), higher awareness of emotional disturbances explained 23% of the variance for anxiety (p=0.022). Impaired awareness explained 33% of the variance for apathy symptom (p<0.001). Unawareness was also associated with higher caregivers’ stress.

Conclusions: In mild AD patients, frequency of unawareness is domain-dependent. The relationship between awareness domains and emotional-behavioural disturbances is independent of demographic and clinical factors.