Journal de biochimie et de biologie cellulaire

Abstrait

Determination of the Cell Orientation Pathway and Receptor Complex Signals

Honey Pitters

Vertebrate proteins activate several distinct pathways. Intrinsic differences among ligands and Frizzled receptors, and the availability of pathway-specific co receptors. A secreted glycoprotein, Cthrc1, is involved in selective activation of the planar cell polarity pathway by proteins. Cell-surface-anchored Cthrc1 bound to proteins, Frizzled proteins, and Ror2 and enhanced the interaction of proteins and Frizzled /Ror2 by forming the Cthrc1 - Frizzled /Ror2 complex. These results suggest that Cthrc1 is a Frizzled cofactor protein that selectively activates the Frizzled /PCP pathway by stabilizing ligand-receptor interaction.