Journal des techniques analytiques et bioanalytiques

Abstrait

Detection of Soluble Oligomers Formed by PB1-F2 Influenza A Virus Protein in vitro

Jasmina Vidic, Ronan Le Goffic, Anna Miodek, Christiane Bourdieu, Charles-Adrien Richard, Mohammed Moudjou, Bernard Delmas and Christophe Chevalier

Influenza A viruses (IAV) remain a major cause of respiratory disease worldwide each year and have been responsible for three main pandemics during the last century comprising the Spanish flu which killed up to 50 million of people. IAV are RNA enveloped viruses belonging to the Orthomyxoviridae family. The nature of the genome of IAV favors the constant and hardly predictable emergence of new strains such as highly virulent H5N1 viruses since 2003, or the H1N1 2009 pandemic strain. Recently, new human cases of severe respiratory illness with a new avian influenza A (H7N9) virus have been reported in China (mortality rate of 60%).Thus, researchers maintain their efforts to determine specific markers of virulence and to evaluate the potential of emerging strains to cause new pandemics.